Grapette was established by B.T. Fooks who also established The Fooks Manufacturing Company. His best selling drink was made using Concord Grapes grown in the northern New York and Pennsylvannia areas. He developed and distributed over 40 fruit cola dirnks to local distributors in consumer markets in Arkansas, Louisiana, Mississippi, and Texas. His company was very successful, which caused him to hire several more workers and so his company expanded.

After trouble with finding a name B.T. went looking for one, he bought the trademark for the names Grapette, Orangette, and Lemonette from Mr. Goldstein for $500, who was the owner of the trademark. His nest unluky encounter was with his company's slogan, which they were forced to withdraw by the government because it implied a natural product. Over the next couple of years, Grapette had the slogans': "The Reason is in the Bottle," "Made Just Right," and "Thirsts Best Bet," and finally one that stuck "Thirsty or Not."

Following this in 1948, due to a wartime restiction new class products were not allowed because most resources were needed for military products. So grapette purchased a large quantity of glass banks from other sources and filled them with the grapette. From these banks they got bottles in the shapes of kittens and bears. But each of these designs had a few problems associated with it, to fix this Grapette Co. engineers developed a new bottle in the form of an elephant. This was followed by a clown of which both were a huge success. In 1952 Grapette introduced its popular twist bottle replacing the privious 6 oz. bottle.

As Grapette Co. expanded it was met with new challenges such as in 1962, when they marketed their Mr. Cola and Mr. Cola Jr. line of berverges. This drink was also ddeveloped by chief chemist Francis Brooker, who worked for Grapette from 1941-1972. Next B.T. was convinced to establish an agency to provide grapette to South America. Following the establishment of the Grapette International in 1964, Grapette produced the first low calorie drinks on the market.

In 1969, Grapette took a turn for the worst because B.T. Fooks considered selling the company and in 1972 did sell the company to the Riengold Corporation in New York. This followed by it being passed on to Manarch Company who simply shelved th product in favor of their own Nugrape line instead of Grapette's line. This marked the end of Grapette in the United States but not in the World.